Complete structure of A/duck/Ukraine/63 influenza hemagglutinin gene: Animal virus as progenitor of human H3 Hong Kong 1968 influenza hemagglutinin
Identifieur interne : 000189 ( 1968/Analysis ); précédent : 000188; suivant : 000190Complete structure of A/duck/Ukraine/63 influenza hemagglutinin gene: Animal virus as progenitor of human H3 Hong Kong 1968 influenza hemagglutinin
Auteurs : Rongxiang Fang [Belgique] ; Willy Min Jou [Belgique] ; Danny Huylebroeck [Belgique] ; René Devos [Belgique] ; Walter Fiers [Belgique]Source :
- Cell [ 0092-8674 ] ; 1981.
English descriptors
- Teeft :
- Aichi, Amino, Amino acid differences, Amino acid sequence, Animal reservoir, Animal virus, Antigenic, Antigenic drift, Antigenic shift, Antigenic sites, Antigenically, Common ancestor, Dopheide, Gene, Gething, Haemagglutinin, Hemagglutinin, Hemagglutinin gene, Hemagglutinin genes, Hemagglutinins, Hinshaw, Hong kong, Hong kong influenza, Human hemagglutinin, Human influenza, Human population, Human virus, Influenza, Influenza virus, Influenza viruses, Laver, Mutation, Neuraminidase, Neuraminidase subtypes, Nucleotide, Palese, Plasmid, Progenitor, Reassortment, Scholtissek, Sequencing, Silent mutations, Skehel, Sleigh, Subtype, Subtypes, Surface antigens, Verhoeyen, Virology, Virus, Year drift period.
Abstract
Abstract: We have explored the possibility that an animal viral reservoir contained a direct ancestor gene for the H3 hemagglutinin type present in influenza A viruses in humans since 1968. For this purpose, the duck/Ukraine/1/63 hemagglutinin gene was cloned and sequenced. From the comparison of its complete primary structure with that of several human H3 hemagglutinins as well as those of an H2 and an H7 hemagglutinin, we conclude that the duck/Ukraine/63 hemagglutinin sequence fully corroborates its previous identification by immunological and other methods as belonging to the H3 subtype. Moreover, the duck/Ukraine/63 amino acid sequence is more closely related structurally and presumably antigenically to the human Aichi/68 hemagglutinin, which formed the beginning of the H3N2 pandemic in humans, than to that of Victoria/75, which has undergone an additional 7 year drift period in humans. This observation could best be explained by a common ancestor hemagglutinin gene for duck/Ukraine/63 and human Aichi/68. On the basis of silent, accumulated base changes, we estimate that the strain carrying this postulated common progenitor hemagglutinin gene was circulating in the period 1949–1953 in the animal reservoir. This relatively recent divergence, as well as the closer kinship between the duck/Ukraine/63 and the human Aichi/68 hemagglutinin, as compared with the later Victoria/75, strongly suggests that the influenza A virus of the H3N2 subtype circulating in the human population since 1968 has derived its hemagglutinin gene from a strain in the animal reservoir. Undoubtedly, this occurred by reassortment between previously present human H2N2 virus and this animal strain. These results provide support at the molecular level for the general idea that the wide variety of influenza viruses known to be present in animals can serve as a gene reservoir for human influenza A viruses.
Url:
DOI: 10.1016/0092-8674(81)90049-0
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000394
- to stream Istex, to step Curation: 000394
- to stream Istex, to step Checkpoint: 001367
- to stream Main, to step Merge: 002880
- to stream Main, to step Curation: 002735
- to stream Main, to step Exploration: 002735
- to stream 1968, to step Extraction: 000189
Links to Exploration step
ISTEX:898743A7BD3F144CA0FE92C01AC19F8E4FA1A04CLe document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Complete structure of A/duck/Ukraine/63 influenza hemagglutinin gene: Animal virus as progenitor of human H3 Hong Kong 1968 influenza hemagglutinin</title><author><name sortKey="Fang, Rongxiang" sort="Fang, Rongxiang" uniqKey="Fang R" first="Rongxiang" last="Fang">Rongxiang Fang</name></author><author><name sortKey="Min Jou, Willy" sort="Min Jou, Willy" uniqKey="Min Jou W" first="Willy" last="Min Jou">Willy Min Jou</name></author><author><name sortKey="Huylebroeck, Danny" sort="Huylebroeck, Danny" uniqKey="Huylebroeck D" first="Danny" last="Huylebroeck">Danny Huylebroeck</name></author><author><name sortKey="Devos, Rene" sort="Devos, Rene" uniqKey="Devos R" first="René" last="Devos">René Devos</name></author><author><name sortKey="Fiers, Walter" sort="Fiers, Walter" uniqKey="Fiers W" first="Walter" last="Fiers">Walter Fiers</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:898743A7BD3F144CA0FE92C01AC19F8E4FA1A04C</idno><date when="1981" year="1981">1981</date><idno type="doi">10.1016/0092-8674(81)90049-0</idno><idno type="url">https://api.istex.fr/ark:/67375/6H6-F27FQDVV-C/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000394</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000394</idno><idno type="wicri:Area/Istex/Curation">000394</idno><idno type="wicri:Area/Istex/Checkpoint">001367</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">001367</idno><idno type="wicri:doubleKey">0092-8674:1981:Fang R:complete:structure:of</idno><idno type="wicri:Area/Main/Merge">002880</idno><idno type="wicri:Area/Main/Curation">002735</idno><idno type="wicri:Area/Main/Exploration">002735</idno><idno type="wicri:Area/1968/Extraction">000189</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Complete structure of A/duck/Ukraine/63 influenza hemagglutinin gene: Animal virus as progenitor of human H3 Hong Kong 1968 influenza hemagglutinin</title><author><name sortKey="Fang, Rongxiang" sort="Fang, Rongxiang" uniqKey="Fang R" first="Rongxiang" last="Fang">Rongxiang Fang</name><affiliation wicri:level="1"><country xml:lang="fr">Belgique</country><wicri:regionArea>Laboratory of Molecular Biology State University of Ghent Ledeganckstraat, 35 B-9000 Ghent</wicri:regionArea><wicri:noRegion>35 B-9000 Ghent</wicri:noRegion></affiliation></author><author><name sortKey="Min Jou, Willy" sort="Min Jou, Willy" uniqKey="Min Jou W" first="Willy" last="Min Jou">Willy Min Jou</name><affiliation wicri:level="1"><country xml:lang="fr">Belgique</country><wicri:regionArea>Laboratory of Molecular Biology State University of Ghent Ledeganckstraat, 35 B-9000 Ghent</wicri:regionArea><wicri:noRegion>35 B-9000 Ghent</wicri:noRegion></affiliation></author><author><name sortKey="Huylebroeck, Danny" sort="Huylebroeck, Danny" uniqKey="Huylebroeck D" first="Danny" last="Huylebroeck">Danny Huylebroeck</name><affiliation wicri:level="1"><country xml:lang="fr">Belgique</country><wicri:regionArea>Laboratory of Molecular Biology State University of Ghent Ledeganckstraat, 35 B-9000 Ghent</wicri:regionArea><wicri:noRegion>35 B-9000 Ghent</wicri:noRegion></affiliation></author><author><name sortKey="Devos, Rene" sort="Devos, Rene" uniqKey="Devos R" first="René" last="Devos">René Devos</name><affiliation wicri:level="1"><country xml:lang="fr">Belgique</country><wicri:regionArea>Laboratory of Molecular Biology State University of Ghent Ledeganckstraat, 35 B-9000 Ghent</wicri:regionArea><wicri:noRegion>35 B-9000 Ghent</wicri:noRegion></affiliation></author><author><name sortKey="Fiers, Walter" sort="Fiers, Walter" uniqKey="Fiers W" first="Walter" last="Fiers">Walter Fiers</name><affiliation wicri:level="1"><country xml:lang="fr">Belgique</country><wicri:regionArea>Laboratory of Molecular Biology State University of Ghent Ledeganckstraat, 35 B-9000 Ghent</wicri:regionArea><wicri:noRegion>35 B-9000 Ghent</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Cell</title><title level="j" type="abbrev">CELL</title><idno type="ISSN">0092-8674</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1981">1981</date><biblScope unit="volume">25</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="315">315</biblScope><biblScope unit="page" to="323">323</biblScope></imprint><idno type="ISSN">0092-8674</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0092-8674</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Aichi</term><term>Amino</term><term>Amino acid differences</term><term>Amino acid sequence</term><term>Animal reservoir</term><term>Animal virus</term><term>Antigenic</term><term>Antigenic drift</term><term>Antigenic shift</term><term>Antigenic sites</term><term>Antigenically</term><term>Common ancestor</term><term>Dopheide</term><term>Gene</term><term>Gething</term><term>Haemagglutinin</term><term>Hemagglutinin</term><term>Hemagglutinin gene</term><term>Hemagglutinin genes</term><term>Hemagglutinins</term><term>Hinshaw</term><term>Hong kong</term><term>Hong kong influenza</term><term>Human hemagglutinin</term><term>Human influenza</term><term>Human population</term><term>Human virus</term><term>Influenza</term><term>Influenza virus</term><term>Influenza viruses</term><term>Laver</term><term>Mutation</term><term>Neuraminidase</term><term>Neuraminidase subtypes</term><term>Nucleotide</term><term>Palese</term><term>Plasmid</term><term>Progenitor</term><term>Reassortment</term><term>Scholtissek</term><term>Sequencing</term><term>Silent mutations</term><term>Skehel</term><term>Sleigh</term><term>Subtype</term><term>Subtypes</term><term>Surface antigens</term><term>Verhoeyen</term><term>Virology</term><term>Virus</term><term>Year drift period</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: We have explored the possibility that an animal viral reservoir contained a direct ancestor gene for the H3 hemagglutinin type present in influenza A viruses in humans since 1968. For this purpose, the duck/Ukraine/1/63 hemagglutinin gene was cloned and sequenced. From the comparison of its complete primary structure with that of several human H3 hemagglutinins as well as those of an H2 and an H7 hemagglutinin, we conclude that the duck/Ukraine/63 hemagglutinin sequence fully corroborates its previous identification by immunological and other methods as belonging to the H3 subtype. Moreover, the duck/Ukraine/63 amino acid sequence is more closely related structurally and presumably antigenically to the human Aichi/68 hemagglutinin, which formed the beginning of the H3N2 pandemic in humans, than to that of Victoria/75, which has undergone an additional 7 year drift period in humans. This observation could best be explained by a common ancestor hemagglutinin gene for duck/Ukraine/63 and human Aichi/68. On the basis of silent, accumulated base changes, we estimate that the strain carrying this postulated common progenitor hemagglutinin gene was circulating in the period 1949–1953 in the animal reservoir. This relatively recent divergence, as well as the closer kinship between the duck/Ukraine/63 and the human Aichi/68 hemagglutinin, as compared with the later Victoria/75, strongly suggests that the influenza A virus of the H3N2 subtype circulating in the human population since 1968 has derived its hemagglutinin gene from a strain in the animal reservoir. Undoubtedly, this occurred by reassortment between previously present human H2N2 virus and this animal strain. These results provide support at the molecular level for the general idea that the wide variety of influenza viruses known to be present in animals can serve as a gene reservoir for human influenza A viruses.</div></front></TEI><affiliations><list><country><li>Belgique</li></country></list><tree><country name="Belgique"><noRegion><name sortKey="Fang, Rongxiang" sort="Fang, Rongxiang" uniqKey="Fang R" first="Rongxiang" last="Fang">Rongxiang Fang</name></noRegion><name sortKey="Devos, Rene" sort="Devos, Rene" uniqKey="Devos R" first="René" last="Devos">René Devos</name><name sortKey="Fiers, Walter" sort="Fiers, Walter" uniqKey="Fiers W" first="Walter" last="Fiers">Walter Fiers</name><name sortKey="Huylebroeck, Danny" sort="Huylebroeck, Danny" uniqKey="Huylebroeck D" first="Danny" last="Huylebroeck">Danny Huylebroeck</name><name sortKey="Min Jou, Willy" sort="Min Jou, Willy" uniqKey="Min Jou W" first="Willy" last="Min Jou">Willy Min Jou</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/1968/Analysis
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000189 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/1968/Analysis/biblio.hfd -nk 000189 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= H2N2V1
|flux= 1968
|étape= Analysis
|type= RBID
|clé= ISTEX:898743A7BD3F144CA0FE92C01AC19F8E4FA1A04C
|texte= Complete structure of A/duck/Ukraine/63 influenza hemagglutinin gene: Animal virus as progenitor of human H3 Hong Kong 1968 influenza hemagglutinin
}}
| This area was generated with Dilib version V0.6.33. |  |